1-(Bromomethyl)-2,4-difluorobenzene → HCID 68661854, compound

HRID 1260884Notes

Reaction equation

HRID 1260884 reaction equation
[NH2:1][C:2]1[N:10]=[CH:9][C:8]([Cl:11])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[Br:12][CH2:13][C:14]1[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=1[F:21]>>[BrH:12].[Cl:11][C:8]1[CH:7]=[C:3]([C:4]([NH2:6])=[O:5])[C:2](=[NH:1])[N:10]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=2[F:21])[CH:9]=1

Participants

3

Reactant 2

HCID 902971-(Bromomethyl)-2,4-difluorobenzeneHCID 668768832-Amino-5-chloronicotinamide

Product 1

HCID 68661854HCID 68661854, compound

Procedure

According to the method of Example 172, 2-amino-5-chloronicotinamide was reacted with 1-(bromomethyl)-2,4-difluorobenzene to give the title compound.

Sources & evidence

ORD record
ord-9ee19a1bc9854902a7ad901198d6c93e
Source dataset
uspto-grants-2013_06
Patent number
US08470859B2

Reaction notes

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