4-(Bromomethyl)-1-fluoro-2-methylbenzene → HCID 68661493, compound

HRID 1260886Notes

Reaction equation

HRID 1260886 reaction equation
[NH2:1][C:2]1[N:10]=[CH:9][C:8]([Cl:11])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].Br[CH2:13][C:14]1[CH:19]=[CH:18][C:17]([F:20])=[C:16]([CH3:21])[CH:15]=1>>[ClH:11].[Cl:11][C:8]1[CH:7]=[C:3]([C:4]([NH2:6])=[O:5])[C:2](=[NH:1])[N:10]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([F:20])=[C:16]([CH3:21])[CH:15]=2)[CH:9]=1

Participants

3

Reactant 2

HCID 27781354-(Bromomethyl)-1-fluoro-2-methylbenzeneHCID 668768832-Amino-5-chloronicotinamide

Product 1

HCID 68661493HCID 68661493, compound

Procedure

According to the method of Example 171, 2-amino-5-chloronicotinamide was reacted with 4-(bromomethyl)-1-fluoro-2-methylbenzene to give the title compound.

Sources & evidence

ORD record
ord-c58712fd9f944c81bbe52246112b02aa
Source dataset
uspto-grants-2013_06
Patent number
US08470859B2

Reaction notes

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