3-(Bromomethyl)-5-fluorobenzonitrile → 5-Chloro-1-(3-cyano-5-fluorobenzyl)-2-imino-1,2-dihydropyridine-3-carboxamide hydrobromide

Participants

Reaction Conditions

Reaction Steps

(Step 4) To a solution of 2-amino-5-chloronicotinamide (0.15 g) in N,N-dimethylformamide (3 ml) was added 3-(bromomethyl)-5-fluorobenzonitrile (0.29 g) obtained in Step 3, and the mixture was stirred at 100° C. for 14 hr. The reaction mixture was diluted with ethyl acetate. The precipitate was collected by filtration and washed with ethyl acetate. The obtained precipitate was recrystallized from methanol-ethyl acetate to give the title compound (69 mg).

Provenance & Evidence