4-(Bromomethyl)-2-chlorobenzonitrile → 5-Chloro-1-(3-chloro-4-cyanobenzyl)-2-imino-1,2-dihydropyridine-3-carboxamide hydrobromide

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-amino-5-chloronicotinamide (0.14 g) in N,N-dimethylformamide (3 ml) was added 4-(bromomethyl)-2-chlorobenzonitrile (0.28 g), and the mixture was stirred at 100° C. for 14 hr. The reaction mixture was diluted with ethyl acetate. The precipitate was collected by filtration and washed with ethyl acetate. The obtained precipitate was recrystallized from methanol-ethyl acetate to give the title compound (85 mg).

Provenance & Evidence