1-Acetylpiperidine-4-carboxylic acid → HCID 68929050, compound

HRID 1260927Notes

Reaction equation

HRID 1260927 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C@H:9]2[C@H:14]([N:15]([CH3:24])[C:16](=[O:23])[C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH2:13][CH2:12][NH:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].[C:25]([N:28]1[CH2:33][CH2:32][CH:31]([C:34](O)=[O:35])[CH2:30][CH2:29]1)(=[O:27])[CH3:26]>>[C:25]([N:28]1[CH2:29][CH2:30][CH:31]([C:34]([N:11]2[CH2:12][CH2:13][C@@H:14]([N:15]([CH3:24])[C:16](=[O:23])[C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C@H:9]([C:4]3[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=3)[CH2:10]2)=[O:35])[CH2:32][CH2:33]1)(=[O:27])[CH3:26]

Participants

3

Reactant 2

HCID 1172551-Acetylpiperidine-4-carboxylic acidHCID 68935247HCID 68935247, compound

Product 1

HCID 68929050HCID 68929050, compound

Procedure

Using the compound obtained in Example 14 and 1-acetylpiperidine-4-carboxylic acid, and by the reaction and purification in the same manner as in Example 3, the title compound was obtained.

Workup

  1. customby the reaction and purification in the same manner as in Example 3

Sources & evidence

ORD record
ord-1aca0a120c9d4aeaa68e266cce3e1100
Source dataset
uspto-grants-2013_06
Patent number
US08470816B2

Reaction notes

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