1-Acetylpiperidine-4-carboxylic acid → HCID 68930374, compound

HRID 1260928Notes

Reaction equation

HRID 1260928 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C@H:9]2[C@H:14]([N:15]([CH3:25])[C:16](=[O:24])[C:17]3[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][CH:18]=3)[CH2:13][CH2:12][NH:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].[C:26]([N:29]1[CH2:34][CH2:33][CH:32]([C:35](O)=[O:36])[CH2:31][CH2:30]1)(=[O:28])[CH3:27]>>[C:26]([N:29]1[CH2:30][CH2:31][CH:32]([C:35]([N:11]2[CH2:12][CH2:13][C@@H:14]([N:15]([CH3:25])[C:16](=[O:24])[C:17]3[CH:18]=[CH:19][C:20]([CH3:23])=[CH:21][CH:22]=3)[C@H:9]([C:4]3[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=3)[CH2:10]2)=[O:36])[CH2:33][CH2:34]1)(=[O:28])[CH3:27]

Participants

3

Reactant 2

HCID 1172551-Acetylpiperidine-4-carboxylic acidHCID 68936644rel-N-[(3R,4R)-3-(3,4-Dichlorophenyl)-4-piperidinyl]-N,4-dimethylbenzamide

Product 1

HCID 68930374HCID 68930374, compound

Procedure

Using the compound obtained in Example 23 and 1-acetylpiperidine-4-carboxylic acid, and by the reaction and purification in the same manner as in Example 3, the title compound was obtained.

Workup

  1. customby the reaction and purification in the same manner as in Example 3

Sources & evidence

ORD record
ord-7d51d145989d4cfd96b121a0518825a2
Source dataset
uspto-grants-2013_06
Patent number
US08470816B2

Reaction notes

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