1-Acetylpiperidine-4-carboxylic acid → HCID 68932659, compound

HRID 1260929Notes

Reaction equation

HRID 1260929 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C@H:9]2[C@H:14]([N:15]([CH3:25])[C:16](=[O:24])[C:17]3[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=3)[CH2:13][CH2:12][NH:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].[C:26]([N:29]1[CH2:34][CH2:33][CH:32]([C:35](O)=[O:36])[CH2:31][CH2:30]1)(=[O:28])[CH3:27]>>[C:26]([N:29]1[CH2:30][CH2:31][CH:32]([C:35]([N:11]2[CH2:12][CH2:13][C@@H:14]([N:15]([CH3:25])[C:16](=[O:24])[C:17]3[CH:18]=[CH:19][C:20]([F:23])=[CH:21][CH:22]=3)[C@H:9]([C:4]3[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=3)[CH2:10]2)=[O:36])[CH2:33][CH2:34]1)(=[O:28])[CH3:27]

Participants

3

Reactant 2

HCID 1172551-Acetylpiperidine-4-carboxylic acidHCID 68930468rel-N-[(3R,4R)-3-(3,4-Dichlorophenyl)-4-piperidinyl]-4-fluoro-N-methylbenzamide

Product 1

HCID 68932659HCID 68932659, compound

Procedure

Using the compound obtained in Example 26 and 1-acetylpiperidine-4-carboxylic acid, and by the reaction and purification in the same manner as in Example 3, the title compound was obtained.

Workup

  1. customby the reaction and purification in the same manner as in Example 3

Sources & evidence

ORD record
ord-e67dcccc870048c4910a6e89f5b31585
Source dataset
uspto-grants-2013_06
Patent number
US08470816B2

Reaction notes

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