1-Acetylpiperidine-4-carboxylic acid → HCID 68929067, compound

HRID 1260931Notes

Reaction equation

HRID 1260931 reaction equation
[Br:1][C:2]1[CH:25]=[CH:24][C:5]([C:6]([N:8]([C@@H:10]2[CH2:15][CH2:14][NH:13][CH2:12][C@H:11]2[C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:17]=2[CH3:23])[CH3:9])=[O:7])=[CH:4][CH:3]=1.[C:26]([N:29]1[CH2:34][CH2:33][CH:32]([C:35](O)=[O:36])[CH2:31][CH2:30]1)(=[O:28])[CH3:27]>>[C:26]([N:29]1[CH2:30][CH2:31][CH:32]([C:35]([N:13]2[CH2:14][CH2:15][C@@H:10]([N:8]([CH3:9])[C:6](=[O:7])[C:5]3[CH:4]=[CH:3][C:2]([Br:1])=[CH:25][CH:24]=3)[C@H:11]([C:16]3[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:17]=3[CH3:23])[CH2:12]2)=[O:36])[CH2:33][CH2:34]1)(=[O:28])[CH3:27]

Participants

3

Reactant 2

HCID 1172551-Acetylpiperidine-4-carboxylic acidHCID 68935364HCID 68935364, compound

Product 1

HCID 68929067HCID 68929067, compound

Procedure

Using the compound obtained in Example 41 and 1-acetylpiperidine-4-carboxylic acid, and by the reaction and purification in the same manner as in Example 3, the title compound was obtained.

Workup

  1. customby the reaction and purification in the same manner as in Example 3

Sources & evidence

ORD record
ord-be091b8ffc7c4542aac017fa293b430d
Source dataset
uspto-grants-2013_06
Patent number
US08470816B2

Reaction notes

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