3,5-Bis(trifluoromethyl)benzoic acid → HCID 86631342, compound

HRID 1260934Notes

Reaction equation

HRID 1260934 reaction equation
C1(C)C=CC(S(O)(=O)=O)=CC=1.[NH2:12][C@@H:13]1[CH2:18][CH2:17][N:16]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:15][C@H:14]1[C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([Cl:32])[CH:27]=1.[F:33][C:34]([F:49])([F:48])[C:35]1[CH:36]=[C:37]([CH:41]=[C:42]([C:44]([F:47])([F:46])[F:45])[CH:43]=1)[C:38](O)=[O:39]>>[F:33][C:34]([F:48])([F:49])[C:35]1[CH:36]=[C:37]([C:38]([NH:12][C@@H:13]2[CH2:18][CH2:17][N:16]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:15][C@H:14]2[C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([Cl:32])[CH:27]=2)=[O:39])[CH:41]=[C:42]([C:44]([F:45])([F:46])[F:47])[CH:43]=1

Participants

3

Reactant 2

HCID 128893,5-Bis(trifluoromethyl)benzoic acidHCID 86631343HCID 86631343, compound

Product 1

HCID 86631342HCID 86631342, compound

Procedure

Using the compound obtained in step 1 and 3,5-bis(trifluoromethyl)benzoic acid, and by the reaction and purification in the same manner as in Reference Example 44, the title compound was obtained.

Workup

  1. customby the reaction and purification in the same manner as in Reference Example 44

Sources & evidence

ORD record
ord-8be0b03fde344bbcb390ebdcfd9384b3
Source dataset
uspto-grants-2013_06
Patent number
US08470816B2

Reaction notes

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