反应详情

To a solution of sodium hydride (60% in oil, 6.36 g) in DMF (100 mL) was added ethyl 1-benzyl-3-oxopiperidine-4-carboxylate monohydrochloride (19.0 g) at 0° C., and the mixture was stirred for 5 min. N-phenylbis(trifluoromethanesulfonimide) (25.0 g) was added, and the mixture was stirred at 0° C. for 1 hr. The reaction mixture was poured into ice water, and the resultant product was extracted with ethyl acetate. The organic layer was washed with water and brine and dried, and the solvent was evaporated under reduced pressure. To a mixture of the obtained residue in a mixed solvent of toluene (125 mL) and water (7.5 mL) were added dihydroxyphenylborane (5.82 g), potassium carbonate (4.40 g) and tetrakis(triphenylphosphine)palladium(0) (3.67 g), and the mixture was stirred under an argon atmosphere at 100° C. for 14 hr. The reaction mixture was poured into water, and the resultant product was extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium hydrogen carbonate solution and brine and dried, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (solvent gradient; 10→20% ethyl acetate/hexane) to give ethyl 1-benzyl-5-phenyl-1,2,3,6-tetrahydropyridine-4-carboxylate (10.2 g) as a pale yellow oil.

1. stirringthe mixture was stirred at 0° C. for 1 hr
2. extractionthe resultant product was extracted with ethyl acetate
3. washThe organic layer was washed with water and brine
4. customdried
5. customthe solvent was evaporated under reduced pressure
6. additionTo a mixture of the obtained residue in a mixed solvent of toluene (125 mL) and water (7.5 mL)
7. additionwere added dihydroxyphenylborane (5.82 g), potassium carbonate (4.40 g) and tetrakis(triphenylphosphine)palladium(0) (3.67 g)
8. stirringthe mixture was stirred under an argon atmosphere at 100° C. for 14 hr
9. additionThe reaction mixture was poured into water
10. extractionthe resultant product was extracted with ethyl acetate
11. washThe organic layer was washed with saturated aqueous sodium hydrogen carbonate solution and brine
12. customdried
13. customthe solvent was evaporated under reduced pressure
14. customThe obtained residue was purified by silica gel column chromatography (solvent gradient; 10→20% ethyl acetate/hexane)