HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1260949Generated: October 29, 2026
Hydrogen chloride-ethyl acetate → HCID 68934061, compound
https://huagongshe.com/reaction/1260949
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrogen chloride-ethyl acetate | HCID 21866389 | — |
| Reactant | rel-1,1-Dimethylethyl (3R,4R)-3-(3,4-dichlorophenyl)-4-[(4-methoxybenzoyl)methylamino]-1-piperidinecarboxylate | HCID 86631352 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 68934061 | HCID 68934061 | 199.4% |
Reaction Steps
To a solution of tert-butyl (3R,4R)-3-(3,4-dichlorophenyl)-4-{[(4-methoxyphenyl)carbonyl](methyl)amino}piperidine-1-carboxylate (700 mg) obtained in Example 169 in ethyl acetate (5 mL) was added 4N hydrogen chloride/ethyl acetate (5 mL), and the mixture was stirred at 50° C. for 4 hr. The reaction mixture was concentrated under reduced pressure to give (3R,4R)-3-(3,4-dichlorophenyl)-4-{[(4-methoxyphenyl)carbonyl](methyl)amino}piperidine monohydrochloride (608 mg, 99%) as a white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08470816B2 |
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| Source dataset | uspto-grants-2013_06 |
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| ORD ID | ord-0861661899f94b948ee66ba974cadaca |
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| Source note | uspto-grants-2013_06 |
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