HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Phenyl-5-(trifluoromethyl)thiophene-2-carboxylic acid → N-[(3R,4R)-1-[(1-acetylpiperidin-4-yl)carbonyl]-3-(3,4-dichlorophenyl)piperidin-4-yl]-N-methyl-4-phenyl-5-(trifluoromethyl)thiophene-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Phenyl-5-(trifluoromethyl)thiophene-2-carboxylic acid | HCID 2783372 | — |
| Reactant | (3R*,4R*)-1-[(1-acetylpiperidin-4-yl)carbonyl]-3-(3,4-dichlorophenyl)-N-methylpiperidin-4-amine | HCID 57741761 | — |
| Product | N-[(3R,4R)-1-[(1-acetylpiperidin-4-yl)carbonyl]-3-(3,4-dichlorophenyl)piperidin-4-yl]-N-methyl-4-phenyl-5-(trifluoromethyl)thiophene-2-carboxamide | HCID 68936609 | — |
Reaction Steps
Using the compound obtained in Example 78 and 4-phenyl-5-(trifluoromethyl)thiophene-2-carboxylic acid, and by the reaction and purification in the same manner as in Example 3, the title compound was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08470816B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-b546df18e9f74ed29dc9fd7eaba47938 |
| Source note | uspto-grants-2013_06 |