1-[2-(trifluoromethyl)phenyl]-1H-imidazole-2-carboxylic acid → N-[(3R,4R)-1-[(1-acetylpiperidin-4-yl)carbonyl]-3-(3,4-dichlorophenyl)piperidin-4-yl]-N-methyl-1-[2-(trifluoromethyl)phenyl]-1H-imidazole-2-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	1-[2-(trifluoromethyl)phenyl]-1H-imidazole-2-carboxylic acid	HCID 2760757	—
Reactant	(3R,4R)-1-[(1-acetylpiperidin-4-yl)carbonyl]-3-(3,4-dichlorophenyl)-N-methylpiperidin-4-amine	HCID 57741761	—
Product	N-[(3R,4R)-1-[(1-acetylpiperidin-4-yl)carbonyl]-3-(3,4-dichlorophenyl)piperidin-4-yl]-N-methyl-1-[2-(trifluoromethyl)phenyl]-1H-imidazole-2-carboxamide	HCID 68935740	—

Reaction Steps

Using the compound obtained in Example 78 and 1-[2-(trifluoromethyl)phenyl]-1H-imidazole-2-carboxylic acid, and by the reaction and purification in the same manner as in Example 3, the title compound was obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08470816B2
Source dataset	uspto-grants-2013_06
ORD ID	ord-3bc8e19e926648eaa5b4d0e58ac2b758
Source note	uspto-grants-2013_06