5-Phenyl-1,3-oxazole-4-carboxylic acid → HCID 68935315, compound

HRID 1260957Notes

Reaction equation

HRID 1260957 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([C:10]([N:12]2[CH2:17][CH2:16][C@@H:15]([NH:18][CH3:19])[C@H:14]([C:20]3[CH:25]=[CH:24][C:23]([Cl:26])=[C:22]([Cl:27])[CH:21]=3)[CH2:13]2)=[O:11])[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[C:28]1([C:34]2[O:38][CH:37]=[N:36][C:35]=2[C:39]([OH:41])=O)[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>>[C:1]([N:4]1[CH2:5][CH2:6][CH:7]([C:10]([N:12]2[CH2:17][CH2:16][C@@H:15]([N:18]([CH3:19])[C:39]([C:35]3[N:36]=[CH:37][O:38][C:34]=3[C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=3)=[O:41])[C@H:14]([C:20]3[CH:25]=[CH:24][C:23]([Cl:26])=[C:22]([Cl:27])[CH:21]=3)[CH2:13]2)=[O:11])[CH2:8][CH2:9]1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 27762995-Phenyl-1,3-oxazole-4-carboxylic acidHCID 57741761(3R*,4R*)-1-[(1-acetylpiperidin-4-yl)carbonyl]-3-(3,4-dichlorophenyl)-N-methylpiperidin-4-amine

Product 1

HCID 68935315HCID 68935315, compound

Procedure

Using the compound obtained in Example 78 and 5-phenyl-1,3-oxazole-4-carboxylic acid, and by the reaction and purification in the same manner as in Example 3, the title compound was obtained.

Workup

  1. customby the reaction and purification in the same manner as in Example 3

Sources & evidence

ORD record
ord-b39740d3fd0b4af3b6592aacd815e320
Source dataset
uspto-grants-2013_06
Patent number
US08470816B2

Reaction notes

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