5-Phenyl-3-isoxazolecarboxylic acid → HCID 68935667, compound

HRID 1260958Notes

Reaction equation

HRID 1260958 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([C:10]([N:12]2[CH2:17][CH2:16][C@@H:15]([NH:18][CH3:19])[C@H:14]([C:20]3[CH:25]=[CH:24][C:23]([Cl:26])=[C:22]([Cl:27])[CH:21]=3)[CH2:13]2)=[O:11])[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[C:28]1([C:34]2[O:38][N:37]=[C:36]([C:39]([OH:41])=O)[CH:35]=2)[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>>[C:1]([N:4]1[CH2:5][CH2:6][CH:7]([C:10]([N:12]2[CH2:17][CH2:16][C@@H:15]([N:18]([CH3:19])[C:39]([C:36]3[CH:35]=[C:34]([C:28]4[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=4)[O:38][N:37]=3)=[O:41])[C@H:14]([C:20]3[CH:25]=[CH:24][C:23]([Cl:26])=[C:22]([Cl:27])[CH:21]=3)[CH2:13]2)=[O:11])[CH2:8][CH2:9]1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 1519165-Phenyl-3-isoxazolecarboxylic acidHCID 57741761(3R*,4R*)-1-[(1-acetylpiperidin-4-yl)carbonyl]-3-(3,4-dichlorophenyl)-N-methylpiperidin-4-amine

Product 1

HCID 68935667HCID 68935667, compound

Procedure

Using the compound obtained in Example 78 and 5-phenylisoxazole-3-carboxylic acid, and by the reaction and purification in the same manner as in Example 3, the title compound was obtained.

Workup

  1. customby the reaction and purification in the same manner as in Example 3

Sources & evidence

ORD record
ord-cb95f347f4914a26a0e04a043a000a88
Source dataset
uspto-grants-2013_06
Patent number
US08470816B2

Reaction notes

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