(3R*,4R*)-1-[(1-acetylpiperidin-4-yl)carbonyl]-3-(3,4-dichlorophenyl)-N-methylpiperidin-4-amine → HCID 68932298, compound

HRID 1260961Notes

Reaction equation

HRID 1260961 reaction equation
[CH3:1][O:2][C:3]1[N:4]=[C:5]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[S:6][C:7]=1[C:8]([OH:10])=O.[C:17]([N:20]1[CH2:25][CH2:24][CH:23]([C:26]([N:28]2[CH2:33][CH2:32][C@@H:31]([NH:34][CH3:35])[C@H:30]([C:36]3[CH:41]=[CH:40][C:39]([Cl:42])=[C:38]([Cl:43])[CH:37]=3)[CH2:29]2)=[O:27])[CH2:22][CH2:21]1)(=[O:19])[CH3:18]>>[C:17]([N:20]1[CH2:21][CH2:22][CH:23]([C:26]([N:28]2[CH2:33][CH2:32][C@@H:31]([N:34]([CH3:35])[C:8]([C:7]3[S:6][C:5]([C:11]4[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=4)=[N:4][C:3]=3[O:2][CH3:1])=[O:10])[C@H:30]([C:36]3[CH:41]=[CH:40][C:39]([Cl:42])=[C:38]([Cl:43])[CH:37]=3)[CH2:29]2)=[O:27])[CH2:24][CH2:25]1)(=[O:19])[CH3:18]

Participants

3

Reactant 2

HCID 57741761(3R*,4R*)-1-[(1-acetylpiperidin-4-yl)carbonyl]-3-(3,4-dichlorophenyl)-N-methylpiperidin-4-amineHCID 68938209HCID 68938209, compound

Product 1

HCID 68932298HCID 68932298, compound

Procedure

Using the compound obtained in step 1 and the compound obtained in Example 78, and by the reaction and purification in the same manner as in Example 3, the title compound was obtained.

Sources & evidence

ORD record
ord-d65f5bc030ed409cacdd9240d34ffda4
Source dataset
uspto-grants-2013_06
Patent number
US08470816B2

Reaction notes

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