HCID 86631391, compound → HCID 86631392, compound

HRID 1260966Notes

Reaction equation

HRID 1260966 reaction equation
[F:1][C:2]([F:49])([F:48])[C:3]1[CH:4]=[C:5]([C:13]([N:15]([CH3:47])[C@@H:16]2[CH2:21][CH2:20][N:19]([C:22](=[O:38])[CH2:23][NH:24][CH:25]3[CH2:30][CH2:29][N:28](C(OC(C)(C)C)=O)[CH2:27][CH2:26]3)[CH2:18][C@H:17]2[C:39]2[CH:44]=[CH:43][C:42]([Cl:45])=[C:41]([Cl:46])[CH:40]=2)=[O:14])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1>Cl.CC(O)C>[ClH:45].[ClH:45].[Cl:46][C:41]1[CH:40]=[C:39]([C@H:17]2[C@H:16]([N:15]([CH3:47])[C:13](=[O:14])[C:5]3[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=[C:3]([C:2]([F:49])([F:48])[F:1])[CH:4]=3)[CH2:21][CH2:20][N:19]([C:22](=[O:38])[CH2:23][NH:24][CH:25]3[CH2:26][CH2:27][NH:28][CH2:29][CH2:30]3)[CH2:18]2)[CH:44]=[CH:43][C:42]=1[Cl:45]

Participants

3

Reactant 1

HCID 86631391HCID 86631391, compound

Product 1

HCID 86631392HCID 86631392, compoundYield 189.6%

Reagents, catalysts & solvents 1

HCID 21912024Isopropanol hydrochlorideSolvent

Procedure

A solution of the compound (0.23 g) obtained in step 1 in 2N hydrogen chloride/2-propanol (5 mL) was stirred at 50° C. for 2 hr. The reaction mixture was concentrated under reduced pressure to give N-[(3R,4R)-3-(3,4-dichlorophenyl)-1-(N-piperidin-4-ylglycyl)piperidin-4-yl]-N-methyl-3,5-bis(trifluoromethyl)benzamide dihydrochloride (0.14 g, 63%) as a white powder.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-405dcab28c7640abb44f97e84fd31e7f
Source dataset
uspto-grants-2013_06
Patent number
US08470816B2

Reaction notes

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