Acetic Acid → HCID 86631394, compound

HRID 1260967Notes

Reaction equation

Cl.Cl.[Cl:3][C:4]1[CH:5]=[C:6]([C@H:11]2[C@H:16]([N:17]([CH3:34])[C:18](=[O:33])[C:19]3[CH:24]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:22]=[C:21]([C:29]([F:32])([F:31])[F:30])[CH:20]=3)[CH2:15][CH2:14][N:13]([C:35](=[O:44])[CH2:36][NH:37][CH:38]3[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]3)[CH2:12]2)[CH:7]=[CH:8][C:9]=1[Cl:10].[C:45](O)(=[O:47])[CH3:46]>>[ClH:3].[C:45]([N:41]1[CH2:40][CH2:39][CH:38]([NH:37][CH2:36][C:35]([N:13]2[CH2:14][CH2:15][C@@H:16]([N:17]([CH3:34])[C:18](=[O:33])[C:19]3[CH:24]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:22]=[C:21]([C:29]([F:32])([F:31])[F:30])[CH:20]=3)[C@H:11]([C:6]3[CH:7]=[CH:8][C:9]([Cl:10])=[C:4]([Cl:3])[CH:5]=3)[CH2:12]2)=[O:44])[CH2:43][CH2:42]1)(=[O:47])[CH3:46]

Participants

Reactant 2

HCID 176Acetic Acid

HCID 86631392HCID 86631392, compound

Product 1

HCID 86631394HCID 86631394, compound

Procedure

Using the compound obtained in step 2 and acetic acid, and by the reaction and purification in the same manner as in Example 3, the title compound was obtained.

Workup

customby the reaction and purification in the same manner as in Example 3

Sources & evidence

ORD record: ord-a7591119361c4f1e841890ba7c2576bc
Source dataset: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08470816B2

Reaction notes

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