Ammonia → HCID 68870762, compound

HRID 1260975Notes

Reaction equation

HRID 1260975 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]([CH3:34])[C@@H:11]2[CH2:16][CH2:15][N:14]([C:17]3[N:22]=[CH:21][C:20]([C:23]([OH:25])=O)=[CH:19][CH:18]=3)[CH2:13][C@H:12]2[C:26]2[CH:31]=[CH:30][C:29]([Cl:32])=[C:28]([Cl:33])[CH:27]=2)=[O:9])=[CH:4][CH:3]=1.[NH3:35]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]([CH3:34])[C@@H:11]2[CH2:16][CH2:15][N:14]([C:17]3[N:22]=[CH:21][C:20]([C:23]([NH2:35])=[O:25])=[CH:19][CH:18]=3)[CH2:13][C@H:12]2[C:26]2[CH:31]=[CH:30][C:29]([Cl:32])=[C:28]([Cl:33])[CH:27]=2)=[O:9])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 689390336-[(3R,4R)-4-[(4-Chlorobenzoyl)methylamino]-3-(3,4-dichlorophenyl)-1-piperidinyl]-3-pyridinecarboxylic acid

Product 1

HCID 68870762HCID 68870762, compound

Procedure

Using the compound obtained in Example 500 and aqueous ammonia, and by the reaction and purification in the same manner as in Example 510, the title compound was obtained.

Workup

  1. customby the reaction and purification in the same manner as in Example 510

Sources & evidence

ORD record
ord-7707aba211e5473e960e87393efa26c4
Source dataset
uspto-grants-2013_06
Patent number
US08470816B2

Reaction notes

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