HCID 68935326, compound → HCID 68932408, compound

HRID 1260982Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([C@H:9]2[C@H:14]([N:15]([CH3:30])[C:16]([C:18]3[CH:23]=[CH:22][C:21]([N:24]4[CH2:29][CH2:28][O:27][CH2:26][CH2:25]4)=[CH:20][CH:19]=3)=[O:17])[CH2:13][CH2:12][N:11]([C:31]([CH:33]3[CH2:38][CH2:37][N:36](C(OC(C)(C)C)=O)[CH2:35][CH2:34]3)=[O:32])[CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]>Cl.CC(O)C>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([C@H:9]2[C@H:14]([N:15]([CH3:30])[C:16](=[O:17])[C:18]3[CH:19]=[CH:20][C:21]([N:24]4[CH2:29][CH2:28][O:27][CH2:26][CH2:25]4)=[CH:22][CH:23]=3)[CH2:13][CH2:12][N:11]([C:31]([CH:33]3[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]3)=[O:32])[CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

Conditions

Temperature: 50 °C

Procedure

To tert-butyl 4-{[(3R,4R)-3-(3,4-dichlorophenyl)-4-{methyl[(4-morpholin-4-ylphenyl)carbonyl]amino}piperidin-1-yl]carbonyl}piperidine-1-carboxylate (800 mg) obtained in Example 620 was added 2N hydrogen chloride/2-propanol (10 mL), and the mixture was stirred at 50° C. for 4 hr. The reaction mixture was concentrated under reduced pressure to give the title compound (771 mg, 100%) as a white powder.

Workup

concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record: ord-abb9fb4ca0fa4ad19cafe1f3ffe04211
Source dataset: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08470816B2

Reaction notes

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