1-Glycoloylpiperidine-4-carboxylic acid → 5-bromo-N-[(3R,4R)-3-(3,4-dichlorophenyl)-1-{[1-(hydroxyacetyl)piperidin-4-yl]carbonyl}piperidin-4-yl]-N-methylpyridine-2-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	1-Glycoloylpiperidine-4-carboxylic acid	HCID 24284839	—
Reactant	5-bromo-N-[(3R,4R)-3-(3,4-dichlorophenyl)piperidin-4-yl]-N-methylpyridine-2-carboxamide	HCID 86631422	—
Product	5-bromo-N-[(3R,4R)-3-(3,4-dichlorophenyl)-1-{[1-(hydroxyacetyl)piperidin-4-yl]carbonyl}piperidin-4-yl]-N-methylpyridine-2-carboxamide	HCID 68932191	—

Reaction Steps

Using the compound obtained in step 1 and 1-(hydroxyacetyl)piperidine-4-carboxylic acid, and by the reaction and purification in the same manner as in Example 265, the title compound was obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08470816B2
Source dataset	uspto-grants-2013_06
ORD ID	ord-858049707c254f069489ed1c19886aff
Source note	uspto-grants-2013_06