Acetyl chloride → HCID 68932510, compound

HRID 1260992Notes

Reaction equation

[Cl:1][C:2]1[CH:34]=[CH:33][C:5]([C:6]([N:8]([C@@H:10]2[CH2:15][CH2:14][N:13]([S:16]([CH:19]3[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]3)(=[O:18])=[O:17])[CH2:12][C@H:11]2[C:25]2[CH:30]=[CH:29][C:28]([Cl:31])=[C:27]([Cl:32])[CH:26]=2)[CH3:9])=[O:7])=[CH:4][CH:3]=1.[C:35](Cl)(=[O:37])[CH3:36]>>[C:35]([N:22]1[CH2:23][CH2:24][CH:19]([S:16]([N:13]2[CH2:14][CH2:15][C@@H:10]([N:8]([CH3:9])[C:6](=[O:7])[C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:34][CH:33]=3)[C@H:11]([C:25]3[CH:30]=[CH:29][C:28]([Cl:31])=[C:27]([Cl:32])[CH:26]=3)[CH2:12]2)(=[O:17])=[O:18])[CH2:20][CH2:21]1)(=[O:37])[CH3:36]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 68937495HCID 68937495, compound

Product 1

HCID 68932510HCID 68932510, compound

Procedure

Using the compound obtained in step 1 and acetyl chloride, and by the reaction and purification in the same manner as in Example 39, the title compound was obtained as a white powder.

Workup

customby the reaction and purification in the same manner as in Example 39

Sources & evidence

ORD record: ord-9fb98424ba804a20b564159cee39ee9a
Source dataset: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08470816B2

Reaction notes

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