1-(Cyclopropylcarbonyl)piperidine-4-carboxylic acid → 4-cyclopropyl-N-[(3R,4R)-1-{[1-(cyclopropylcarbonyl)piperidin-4-yl]carbonyl}-3-(3,4-dichlorophenyl)piperidin-4-yl]-N-methylbenzamide

HRID 1260994Notes

Reaction equation

HRID 1260994 reaction equation
[CH:1]1([C:4]2[CH:27]=[CH:26][C:7]([C:8]([N:10]([C@@H:12]3[CH2:17][CH2:16][NH:15][CH2:14][C@H:13]3[C:18]3[CH:23]=[CH:22][C:21]([Cl:24])=[C:20]([Cl:25])[CH:19]=3)[CH3:11])=[O:9])=[CH:6][CH:5]=2)[CH2:3][CH2:2]1.[CH:28]1([C:31]([N:33]2[CH2:38][CH2:37][CH:36]([C:39](O)=[O:40])[CH2:35][CH2:34]2)=[O:32])[CH2:30][CH2:29]1>>[CH:1]1([C:4]2[CH:27]=[CH:26][C:7]([C:8]([N:10]([C@@H:12]3[CH2:17][CH2:16][N:15]([C:39]([CH:36]4[CH2:35][CH2:34][N:33]([C:31]([CH:28]5[CH2:30][CH2:29]5)=[O:32])[CH2:38][CH2:37]4)=[O:40])[CH2:14][C@H:13]3[C:18]3[CH:23]=[CH:22][C:21]([Cl:24])=[C:20]([Cl:25])[CH:19]=3)[CH3:11])=[O:9])=[CH:6][CH:5]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 89029151-(Cyclopropylcarbonyl)piperidine-4-carboxylic acidHCID 689352624-cyclopropyl-N-[(3R,4R)-3-(3,4-dichlorophenyl)piperidin-4-yl]-N-methylbenzamide

Product 1

HCID 689324334-cyclopropyl-N-[(3R,4R)-1-{[1-(cyclopropylcarbonyl)piperidin-4-yl]carbonyl}-3-(3,4-dichlorophenyl)piperidin-4-yl]-N-methylbenzamide

Procedure

Using the compound obtained in Example 649, step 1 and 1-(cyclopropylcarbonyl)piperidine-4-carboxylic acid, and by the reaction and purification in the same manner as in Example 97, the title compound was obtained.

Workup

  1. customby the reaction and purification in the same manner as in Example 97

Sources & evidence

ORD record
ord-1a2e85b76c3645f883a7855990381f34
Source dataset
uspto-grants-2013_06
Patent number
US08470816B2

Reaction notes

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