1-(Cyclopropylcarbonyl)piperidine-4-carboxylic acid → 5-bromo-N-[(3R,4R)-1-{[1-(cyclopropylcarbonyl)piperidin-4-yl]carbonyl}-3-(3,4-dichlorophenyl)piperidin-4-yl]-N-methylpyridine-2-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	1-(Cyclopropylcarbonyl)piperidine-4-carboxylic acid	HCID 8902915	—
Reactant	5-bromo-N-[(3R,4R)-3-(3,4-dichlorophenyl)piperidin-4-yl]-N-methylpyridine-2-carboxamide	HCID 86631422	—
Product	5-bromo-N-[(3R,4R)-1-{[1-(cyclopropylcarbonyl)piperidin-4-yl]carbonyl}-3-(3,4-dichlorophenyl)piperidin-4-yl]-N-methylpyridine-2-carboxamide	HCID 68931977	—

Reaction Steps

Using the compound obtained in Example 648, step 1 and 1-(cyclopropylcarbonyl)piperidine-4-carboxylic acid, and by the reaction and purification in the same manner as in Example 97, the title compound was obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08470816B2
Source dataset	uspto-grants-2013_06
ORD ID	ord-29fa51fca72e43b29407ea6815ff5358
Source note	uspto-grants-2013_06