Water → HCID 68939062, compound

HRID 1260997Notes

Reaction equation

HRID 1260997 reaction equation
C([O:4][C@H:5]1[CH2:10][CH2:9][C@H:8]([C:11]([N:13]2[CH2:18][CH2:17][C@@H:16]([N:19]([C:21]([C:23]3[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=3)=[O:22])[CH3:20])[C@H:15]([C:30]3[CH:35]=[CH:34][C:33]([Cl:36])=[C:32]([Cl:37])[CH:31]=3)[CH2:14]2)=[O:12])[CH2:7][CH2:6]1)(=O)C.C(=O)([O-])[O-].[Na+].[Na+].O>CO>[Cl:29][C:26]1[CH:27]=[CH:28][C:23]([C:21]([N:19]([C@@H:16]2[CH2:17][CH2:18][N:13]([C:11]([CH:8]3[CH2:9][CH2:10][CH:5]([OH:4])[CH2:6][CH2:7]3)=[O:12])[CH2:14][C@H:15]2[C:30]2[CH:35]=[CH:34][C:33]([Cl:36])=[C:32]([Cl:37])[CH:31]=2)[CH3:20])=[O:22])=[CH:24][CH:25]=1

Participants

5

Reactant 3

HCID 962WaterHCID 10340Sodium CarbonateHCID 178476596HCID 178476596, compound

Product 1

HCID 68939062HCID 68939062, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of the compound obtained in Example 518 (0.103 g) in methanol (1.8 mL) was added sodium carbonate (0.067 g) and the mixture was stirred at room temperature. The reaction mixture was poured into water, and the resultant product was extracted with ethyl acetate. The organic layer was washed with brine and dried, and the solvent was evaporated under reduced pressure to give the title compound (0.076 g, 80%) as a white powder.

Workup

  1. extractionthe resultant product was extracted with ethyl acetate
  2. washThe organic layer was washed with brine
  3. customdried
  4. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-d4cb5728589047259fe658f3ef1fa315
Source dataset
uspto-grants-2013_06
Patent number
US08470816B2

Reaction notes

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