Lithium Hydroxide → HCID 58986250, compound

Participants

Role	Name	HCID	Charge
Reactant	Lithium Hydroxide	HCID 3939	—
Reactant	ethyl (3-(2,4-dichlorophenyl)-1-{3-phenyl-1-[4-(trifluoromethyl)phenyl]propyl}-4,5,6,7-tetrahydro-1H-indo 1-7-yl)acetate	HCID 86761122	—
Solvent	Water	HCID 962	—
Solvent	Ethyl Acetate	HCID 8857	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	HCID 58986250	HCID 58986250	—

Reaction Conditions

Temperature	60 °C

Reaction Steps

The ester from the foregoing step (0.03 g, 0.05 mmol) was dissolved in a mixture of dioxane (7 ml)/water (2 ml). Then LiOH (12 mg, 0.5 mmol) was added and the solution heated to 60° C. for 14 h. The reaction mixture was then diluted with AcOEt (20 ml), washed with 2.0N HCl (20 ml), brine (20 ml), dried over Na2SO4 and concentrated in vacuo. The residue was purified by chromatography on silica gel eluting with 20% AcOEt/Hexane and consequently by HPLC (gradient 60-98% CH3CN/0.1% TFA-H20) to afford 1.2 mg of the title compound; m/z (ES+) 586 (MH+); m/z (ES−) 584 (M−H+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07728022B2
Source dataset	uspto-grants-2010_06
ORD ID	ord-f60a963a40874eb2bc297b9753793e5a
Source note	uspto-grants-2010_06