HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromothiazole → 7-Chloro-2-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)thieno[3,2-b]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromothiazole | HCID 76430 | — |
| Reactant | 7-Chloro-2-(1,3-thiazol-2-yl)thieno[3,2-b]pyridine | HCID 22143663 | — |
| Reactant | 7-Chloro-2-(tributylstannyl)thieno[3,2-b]pyridine | HCID 57516658 | — |
| Reactant | 2-Bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole | HCID 59424542 | — |
| Product | 7-Chloro-2-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)thieno[3,2-b]pyridine | HCID 59424670 | — |
Reaction Steps
Starting from the compound 98 (scheme 19) and following the procedure described above for the synthesis of compound 10 (example 12, scheme 2) but substituting 2-bromothiazole in the step 2 for the bromide 108, title compound 109 was obtained as a white solid (22 mg, 41% yield). MS (m/z) 366.1/368.1 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08470850B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-74da1a2a3f844ef4b77670cb65bbae2f |
| Source note | uspto-grants-2013_06 |