7-(2-Fluoro-4-nitrophenoxy)-2-(thiazol-2-yl)thieno[3,2-b]pyridine → Methyl 2-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)-1-methyl-1H-imidazole-5-carboxylate

HRID 1261242Notes

Reaction equation

HRID 1261242 reaction equation
[F:1][C:2]1[CH:22]=[C:21]([N+:23]([O-:25])=[O:24])[CH:20]=[CH:19][C:3]=1[O:4]C1C=CN=C2C=C(C3SC=CN=3)SC=12.Cl[C:27]1[CH:32]=[CH:31][N:30]=[C:29]2[CH:33]=[C:34]([C:36]3[N:37]([CH3:45])[C:38]([C:41]([O:43][CH3:44])=[O:42])=[CH:39][N:40]=3)[S:35][C:28]=12>>[F:1][C:2]1[CH:22]=[C:21]([N+:23]([O-:25])=[O:24])[CH:20]=[CH:19][C:3]=1[O:4][C:27]1[CH:32]=[CH:31][N:30]=[C:29]2[CH:33]=[C:34]([C:36]3[N:37]([CH3:45])[C:38]([C:41]([O:43][CH3:44])=[O:42])=[CH:39][N:40]=3)[S:35][C:28]=12

Participants

3

Reactant 2

HCID 594244257-(2-Fluoro-4-nitrophenoxy)-2-(thiazol-2-yl)thieno[3,2-b]pyridineHCID 59424560Methyl 2-(7-chlorothieno[3,2-b]pyridin-2-yl)-1-methyl-1H-imidazole-5-carboxylate

Product 1

HCID 59424532Methyl 2-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)-1-methyl-1H-imidazole-5-carboxylate

Procedure

Following the procedure described above for the synthesis of compound 11 (example 12, step 3, scheme 2) but substituting compound 10 for compound 119, title compound 120 was obtained as a yellow solid (254 mg, 31% yield). MS (m/z) 429.1 (M+H).

Sources & evidence

ORD record
ord-b849d154ec444c55bb00eed32abf8732
Source dataset
uspto-grants-2013_06
Patent number
US08470850B2

Reaction notes

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