HCID 86604167, compound → HCID 86604169, compound

HRID 1261249Notes

Reaction equation

HRID 1261249 reaction equation
[ClH:1].[F:2][C:3]1[CH:4]=[C:5]([NH:27][C:28]([NH:30][C:31](=[O:39])[CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)=[S:29])[CH:6]=[CH:7][C:8]=1[O:9][C:10]1[CH:15]=[CH:14][N:13]=[C:12]2[CH:16]=[C:17]([C:19]([N:21]3[CH2:26][CH2:25][CH2:24][CH2:23]C3)=[O:20])[S:18][C:11]=12.FC1C=C(NC(NC(=O)CC2C=CC=CC=2)=S)C=CC=1OC1C=CN=C2C=C(C(N3CCCCC3)=O)SC=12>>[ClH:1].[F:2][C:3]1[CH:4]=[C:5]([NH:27][C:28]([NH:30][C:31](=[O:39])[CH2:32][C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=2)=[S:29])[CH:6]=[CH:7][C:8]=1[O:9][C:10]1[CH:15]=[CH:14][N:13]=[C:12]2[CH:16]=[C:17]([C:19]([N:21]3[CH2:23][CH2:24][CH2:25][CH2:26]3)=[O:20])[S:18][C:11]=12

Participants

3

Reactant 2

HCID 86604167HCID 86604167, compoundHCID 86604168HCID 86604168, compound

Product 1

HCID 86604169HCID 86604169, compound

Procedure

Following the procedure described above for the synthesis of compound 136a (example 93) but substituting compound 135d (example 92, table 11) for the compound 8o (example 37, table 6), title compound 136b was obtained. Characterization of this material is provided in Table 12.

Sources & evidence

ORD record
ord-826cafcd19cb4fd3b22e4e9a2f1625ef
Source dataset
uspto-grants-2013_06
Patent number
US08470850B2

Reaction notes

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