HCID 86604167, compound → HCID 86604170, compound

HRID 1261250Notes

Reaction equation

HRID 1261250 reaction equation
[ClH:1].FC1C=C(NC(NC(=O)CC2C=CC=CC=2)=S)C=CC=1OC1C=CN=C2C=C(C(N3CCCCC3)=O)SC=12.FC1C=C(NC(NC(=O)CC2C=CC=CC=2)=S)C=CC=1OC1C=CN=C2C=C(C(N3CCCCC3)=O)SC=12.[F:78][C:79]1[CH:108]=[C:107]([NH:109][C:110]([NH:112][C:113](=[O:121])[CH2:114][C:115]2[CH:120]=[CH:119][CH:118]=[CH:117][CH:116]=2)=[S:111])[CH:106]=[CH:105][C:80]=1[O:81][C:82]1[CH:87]=[CH:86][N:85]=[C:84]2[CH:88]=[C:89]([C:91]([N:93]3[CH2:97][CH2:96][CH2:95][C@H:94]3[C:98]([O:100]C(C)(C)C)=[O:99])=[O:92])[S:90][C:83]=12>>[ClH:1].[F:78][C:79]1[CH:108]=[C:107]([NH:109][C:110]([NH:112][C:113](=[O:121])[CH2:114][C:115]2[CH:116]=[CH:117][CH:118]=[CH:119][CH:120]=2)=[S:111])[CH:106]=[CH:105][C:80]=1[O:81][C:82]1[CH:87]=[CH:86][N:85]=[C:84]2[CH:88]=[C:89]([C:91]([N:93]3[CH2:97][CH2:96][CH2:95][C@H:94]3[C:98]([OH:100])=[O:99])=[O:92])[S:90][C:83]=12

Participants

4

Reactant 3

HCID 86604167HCID 86604167, compoundHCID 86604168HCID 86604168, compoundHCID 86604172HCID 86604172, compound

Product 1

HCID 86604170HCID 86604170, compound

Procedure

Following the procedure described above for the synthesis of compound 136a (Example 93) but substituting compound 135d (example 92, table 11) for the compound 135a (Example 89, Table 11), title compound 136c was obtained. Characterization of this material is provided in Table 12.

Sources & evidence

ORD record
ord-9e350983695649afb3324a359c463685
Source dataset
uspto-grants-2013_06
Patent number
US08470850B2

Reaction notes

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