HRID1261262

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CS(=O)(=O)c1ccc(-c2cc3nccc(Oc4ccc(N)cc4F)c3s2)cc1

HCID58772869

未命名化合物

结构：CS(=O)(=O)c1ccc(-c2cc3nccc(Oc4ccc(NC(=S)NC(=O)Cc5ccccc5)cc4F)c3s2)cc1

HCID58772875

未命名化合物

结构：Nc1ccc(Oc2ccnc3cc(-c4cccc(OCCN5CCOCC5)c4)sc23)c(F)c1

HCID59424664

未命名化合物

PRODUCTS

生成物

结构：O=C(Cc1ccccc1)NC(=S)Nc1ccc(Oc2ccnc3cc(-c4cccc(OCCN5CCOCC5)c4)sc23)c(F)c1

HCID86604178

未命名化合物

收率 29%

PROCEDURE

实验过程

Following the procedure described above for the synthesis of compound 50 (scheme 10, example 55) but substituting amine 49 for the amine 162, title compound 163a was obtained in 29% yield. Characterization of 163a is provided in the table 15.[LRMS (M+1) 643.3 (100%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-42839cc104e6433bae98b8b5327a30da
来源数据集: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08470850B2
来源说明: uspto-grants-2013_06

反应 SMILES

[F:1][C:2]1[CH:3]=[C:4]([NH:28][C:29]([NH:31][C:32](=[O:40])[CH2:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)=[S:30])[CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]2[CH:15]=[C:16]([C:18]3[CH:23]=[CH:22][C:21](S(C)(=O)=O)=[CH:20][CH:19]=3)[S:17][C:10]=12.FC1C=C(N)C=CC=1OC1C=CN=C2C=C(C3C=CC(S(C)(=O)=O)=CC=3)SC=12.FC1C=C(N)C=CC=1OC1C=CN=C2C=C(C3C=CC=C([O:92][CH2:93][CH2:94][N:95]4[CH2:100][CH2:99][O:98][CH2:97][CH2:96]4)C=3)SC=12>>[F:1][C:2]1[CH:3]=[C:4]([NH:28][C:29]([NH:31][C:32](=[O:40])[CH2:33][C:34]2[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=2)=[S:30])[CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]2[CH:15]=[C:16]([C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([O:92][CH2:93][CH2:94][N:95]4[CH2:100][CH2:99][O:98][CH2:97][CH2:96]4)[CH:19]=3)[S:17][C:10]=12