N-(3-Fluoro-4-(thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide → 2-(2,6-Difluorophenyl)-N-(3-fluoro-4-(thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)acetamide

Participants

Role	Name	HCID	Charge
Reactant	N-(3-Fluoro-4-(thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide	HCID 24901699	—
Reactant	2-(2,6-Difluorophenyl)acetyl isothiocyanate	HCID 80381799	—
Reactant	1-(4-(7-Benzyl-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)-3-fluorophenyl)-3-(2-phenylacetyl)thiourea	HCID 86609660	—
Product	2-(2,6-Difluorophenyl)-N-(3-fluoro-4-(thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)acetamide	HCID 86604182	23%

Reaction Steps

Starting from the amine 169 (scheme 33), following the procedures described above for the synthesis of compound 170a (example 133) but replacing 2-phenylacetyl isothiocyanate with 2-(2,6-difluorophenyl)acetyl isothiocyanate, title compound 192c was obtained in 23% yield. Characterization of 192c is provided in table 18.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08470850B2
Source dataset	uspto-grants-2013_06
ORD ID	ord-8b5f0a89a9ad4faeb7c343e46680af68
Source note	uspto-grants-2013_06