HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-1-methyl-1H-imidazole → 7-chloro-2-(1-methyl-1H-imidazol-2-yl)-thieno[3,2-b]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-1-methyl-1H-imidazole | HCID 2773262 | — |
| Reactant | Tributylstannanyl | HCID 3032732 | — |
| Reactant | 7-Chloro-2-(1,3-thiazol-2-yl)thieno[3,2-b]pyridine | HCID 22143663 | — |
| Product | 7-chloro-2-(1-methyl-1H-imidazol-2-yl)-thieno[3,2-b]pyridine | HCID 22143563 | 95% |
Reaction Steps
Starting from tributyltin compound 98 (scheme 19) and following the procedure described above for the synthesis of compound 10 (scheme 2, step 2, example 12) but replacing 2-bromothiazole with 2-bromo-1-methyl-1H-imidazole, title compound 214 was obtained in 95% yield. MS (m/z) 250.1 (100%), 252.1 (37%), (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08470850B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-61c822bb05664089b710a53123e2a56d |
| Source note | uspto-grants-2013_06 |