4-Bromo-1-methyl-1H-imidazole → 7-Chloro-2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridine

Participants

Role	Name	HCID	Charge
Reactant	4-Bromo-1-methyl-1H-imidazole	HCID 1277653	—
Reactant	7-Chloro-2-(1,3-thiazol-2-yl)thieno[3,2-b]pyridine	HCID 22143663	—
Reactant	7-Chloro-2-(tributylstannyl)thieno[3,2-b]pyridine	HCID 57516658	—
Product	7-Chloro-2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridine	HCID 59424524	29%

Reaction Steps

Starting from the compound 98 (scheme 19), following the procedure described above for the synthesis of compound 10 (scheme 2, step 2, example 12) but replacing 2-bromothiazole with 4-bromo-1-methyl-1H-imidazole, title compound 224 was obtained in 29% yield. MS (m/z): 250.1 (100%), 252.1 (37%) (M+1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08470850B2
Source dataset	uspto-grants-2013_06
ORD ID	ord-f09f8641df2b4469b6ae52400ae47a28
Source note	uspto-grants-2013_06