3,5-Dimethylphenol → 5-(3,5-Dimethylphenoxy)pentanoic acid

HRID 1261378Notes

Reaction equation

HRID 1261378 reaction equation
CC1C=CC=CC=1O[CH2:5][CH2:6][CH2:7][CH2:8][C:9]([OH:11])=[O:10].[CH3:16][C:17]1[CH:18]=[C:19]([OH:24])[CH:20]=[C:21]([CH3:23])[CH:22]=1>>[CH3:16][C:17]1[CH:18]=[C:19]([CH:20]=[C:21]([CH3:23])[CH:22]=1)[O:24][CH2:5][CH2:6][CH2:7][CH2:8][C:9]([OH:11])=[O:10]

Participants

3

Reactant 2

HCID 79483,5-DimethylphenolHCID 289716655-(2-Methylphenoxy)pentanoic acid

Product 1

HCID 289716555-(3,5-Dimethylphenoxy)pentanoic acid

Procedure

5-(3,5-Dimethylphenoxy)pentanoic acid 26d was prepared in the same manner as 26b, except that 3,5-dimethylphenol was used as the starting material. 1H NMR (CDCl3, 400 MHz): 6.58 (s, 1H), 6.51 (s, 2H), 3.94 (t, 2H, J=5.6 Hz), 2.44 (t, 2H, J=7.2 Hz), 2.27 (s, 6H), 1.83 (m, 4H). MS (ESI): 245 [M+Na]+.

Sources & evidence

ORD record
ord-d56911e0823b43dcabc18f05784a538a
Source dataset
uspto-grants-2013_06
Patent number
US08470861B2

Reaction notes

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