3-Bromopropionic acid → HCID 16791468, compound

HRID 1261379Notes

Reaction equation

HRID 1261379 reaction equation
[CH3:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[S:7]CCCCC(O)=O.Br[CH2:16][CH2:17][C:18]([OH:20])=[O:19]>>[CH3:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[S:7][CH2:16][CH2:17][C:18]([OH:20])=[O:19]

Participants

3

Reactant 2

HCID 115533-Bromopropionic acidHCID 12381196HCID 12381196, compound

Product 1

HCID 16791468HCID 16791468, compound

Procedure

3-(1-methyl-1H-imidazol-2-ylthio)propanoic acid 28a was prepared as described for 5-(1-methyl-1H-imidazol-2-ylthio)pentanoic acid (Tweit, et al. (1973) J. Med. Chem. 16:1161), except that 3-bromopropanoic acid was used as the starting material. 1H NMR (400 MHz, CDCl3): 2.62-2.65 (t, 2H, J=6.4 Hz), 3.13-3.16 (t, 2H, J=6.4 Hz), 3.73 (s, 3H), 7.34-7.35 (d, 1H, J=2.1 Hz), 7.38-7.39 (d, 1H, J=2.1 Hz), 11 (br s, 1H). MS (ESI): 187 [M+H]+.

Sources & evidence

ORD record
ord-bd67b1c942154f5699ae263a0c7622ab
Source dataset
uspto-grants-2013_06
Patent number
US08470861B2

Reaction notes

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