HuagongsheHuagongshe Chemistry Print Report · For research reference only
Fluprostenol → HCID 178459549, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Fluprostenol | HCID 5311100 | — |
| Reactant | HCID 178418600 | HCID 178418600 | — |
| Solvent | Methanol--water (1/1) | HCID 22242641 | — |
| Product | HCID 178459549 | HCID 178459549 | — |
Reaction Steps
To travoprost free acid ((+)-fluprostenol free acid) 3 in MeOH/H2O was added L-Arginine (>98%) (Sigma-Aldrich Cat. A5006) and the solution was stirred for 30 minutes. The solvents were evaporated then azeotroped with Et2O and hexanes to give white crystalline travoprost-L-Arginine salt 4 (quantitative).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08470882B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-ae29e2a5412e4ae482ee3861fc8ecd92 |
| Source note | uspto-grants-2013_06 |