Butylamine → HCID 178449181, compound

Participants

Reaction Steps

A mixture of 33 g of N-butylamine (0.45 mol) and of 19 g of diisopropylcarbodiimide (0.15 mol) is refluxed for 3 h 30. The GC analysis then shows a conversion of greater than 99.5% of the diisopropylcarbodiimide. The colorless final mixture is concentrated at 60° C. under 20 mbar for 2 h, to give 29 g of a colorless and virtually odorless liquid of low viscosity, corresponding to the expected guanidine (yield 96.7%). 1H NMR/CDCl3 (ppm): 0.93 (3 H, t), 1.14 (12 H, d), 1.37 (2 H, sex), 1.52 (2 H, quint), 3.01 (2 H, t), 3.57 (2 H, m).

Provenance & Evidence