N-Methylbutylamine → HCID 58238472, compound

HRID 1261466Notes

Reaction equation

HRID 1261466 reaction equation
[CH2:1]([NH:5][CH3:6])[CH2:2][CH2:3][CH3:4].[CH:7]1([N:13]=[C:14]=[N:15][CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1>>[CH2:1]([N:5]([CH3:6])[C:14]([NH:13][CH:7]1[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12]1)=[N:15][CH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 8068N-MethylbutylamineHCID 10868Dicyclohexylcarbodiimide2×

Product 1

HCID 58238472HCID 58238472, compoundYield 99.7%

Procedure

A mixture of 17.78 g of N-butyl-N-methylamine (0.204 mol) and of 21.05 g of dicyclohexylcarbodiimide (0.102 mol) is refluxed for 3 h. The GC analysis then shows a conversion of greater than 99.5% of the dicyclohexylcarbodiimide. The colorless final mixture is concentrated at 60° C. under 1 mbar for 2 h, to give 29.9 g of a colorless and virtually odorless liquid of medium viscosity, corresponding to the expected guanidine (yield 99.7%).

Workup

  1. concentrationThe colorless final mixture is concentrated at 60° C. under 1 mbar for 2 h
  2. customto give 29.9 g of a colorless and virtually odorless liquid of medium viscosity

Sources & evidence

ORD record
ord-be8f9c5a7b0048b0b402b06fef71311f
Source dataset
uspto-grants-2013_06
Patent number
US08470899B2

Reaction notes

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