反应详情

温度

70 °C

2-piperazin-1-yl-ethanol (0.61 g) and ethanol (20 mL) were charged to a 100 mL RB flask equipped with a magnetic stirrer. The mixture was stirred and heated to 70° C. 1,5-Di(tert-butyl)-3-(oxiranylmethylpropyl)-1,1,3,5,5-Pentamethyltrisiloxane (2.0 g) was placed in an addition funnel and added dropwise to the flask. The mixture was stirred and maintained at 70° C. for an additional 4 hours. The reaction progress was monitored by NMR spectroscopy. Upon reaction completion, the ethanol was removed by rotovap, and the mixture was distilled under reduced pressure to remove impurities.

1. customequipped with a magnetic stirrer
2. additionadded dropwise to the flask
3. stirringThe mixture was stirred
4. temperaturemaintained at 70° C. for an additional 4 hours
5. customUpon reaction completion
6. customthe ethanol was removed by rotovap
7. distillationthe mixture was distilled under reduced pressure
8. customto remove impurities