Cesium carbonate → Ethyl 3''-tert-butyl-4'-[4-(tert-butyldimethylsilanyloxy)butoxy]-4''-pyrrolidin-4-yl[1,1';3',1'']terphenyl-4-carboxylate

Participants

Reaction Steps

In a manner similar to that of Example 2a, by reacting 123 mg of ethyl 3″-tert-butyl-4′-hydroxy-4″-pyrrolidin-1-yl[1,1′;3′,1″]terphenyl-4-carboxylate (0.27 mmol) with 110 mg (0.34 mmol) of caesium carbonate and 80 μL of 1-bromo-4-(tert-butyldimethylsilanyloxy)butane (0.30 mmol), 170 mg of ethyl 3″-tert-butyl-4′-[4-(tert-butyldimethylsilanyloxy)butoxy]-4″-pyrrolidin-1-yl[1,1′;3′,1″]terphenyl-4-carboxylate are obtained (yield=97%) in the form of an oil.

Provenance & Evidence