Sodium Hydroxide → HCID 11692261, compound

HRID 1261538Notes

Reaction equation

[C:1]([C:5]1[CH:6]=[C:7]([C:16]2[CH:17]=[C:18]([C:31]3[CH:36]=[CH:35][C:34]([C:37]([O:39]CC)=[O:38])=[CH:33][CH:32]=3)[CH:19]=[CH:20][C:21]=2[O:22][CH2:23][CH2:24][CH2:25][CH2:26][NH:27][CH:28]([CH3:30])[CH3:29])[CH:8]=[CH:9][C:10]=1[N:11]([CH2:14][CH3:15])[CH2:12][CH3:13])([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+]>>[C:1]([C:5]1[CH:6]=[C:7]([C:16]2[CH:17]=[C:18]([C:31]3[CH:32]=[CH:33][C:34]([C:37]([OH:39])=[O:38])=[CH:35][CH:36]=3)[CH:19]=[CH:20][C:21]=2[O:22][CH2:23][CH2:24][CH2:25][CH2:26][NH:27][CH:28]([CH3:29])[CH3:30])[CH:8]=[CH:9][C:10]=1[N:11]([CH2:12][CH3:13])[CH2:14][CH3:15])([CH3:4])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 66671890HCID 66671890, compound

Product 1

HCID 11692261HCID 11692261, compoundYield 25%

Procedure

In a manner similar to that of Example 3, by reacting 190 mg of ethyl 3″-tert-butyl-4″-diethylamino-4′-(4-isopropylaminobutoxy)-[1,1′;3′,1″]terphenyl-4-carboxylate (0.3 mmol) with 0.5 mL of 1N sodium hydroxide solution, 45 mg of 3″-tert-butyl-4″-diethylamino-4′-(4-isopropylaminobutog)-[1,1′;3′,1″]terphenyl-4-carboxylic acid are obtained (yield=25%) in the form of a white solid.

Workup

customare obtained (yield=25%) in the form of a white solid

Sources & evidence

ORD record: ord-6b180831a3874bec8a02481e8b0753fd
Source dataset: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08470871B2

Reaction notes

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