Acetic Acid → HCID 11539622, compound

Participants

Reaction Steps

900 mg (1.74 mmol; 1 eq.) of ethyl 4′-(3-acetoxypropoxy)-3″-tert-butyl-4″-ethylamino-[1,1′;3′,1″]terphenyl-4-benzoate are dissolved in 10 ml of absolute ethanol. 312 mg (7.8 mmol; 4.5 eq.) of sodium hydroxide and 4 ml of H2O are added at room temperature and the mixture is then heated to reflux. These conditions are maintained for about 1 hour 30 minutes. The reaction medium is concentrated to a small volume; H2O is added to the precipitate formed, and the mixture is then acidified with acetic acid to pH ˜4-5. This suspension is fluidized by adding H2O and stirred at room temperature for 1 hour. The resulting mixture is filtered through a sinter funnel, rinsed with H2O until the filtrate is neutral, and oven-dried. 694 mg of 3″-tert-butyl-4″-ethylamino-4′-(3-hydroxypropoxy)-[1,1′;3′,1″]terphenyl-4-carboxylic acid are thus obtained in the form of a white powder (yield=89%).

Provenance & Evidence