GlyTouCan:G06186NU → L-glucose monohydrate

In another embodiment, the process comprises: a) dispersing an amount from about 0.9 moles per liter to about 1.5 moles per liter of a source of L-glucose in water at a temperature of from about 55° C. to not more than about 65° C. at a reduced pressure of at least about 700 mm Hg less than atmospheric pressure, reducing the amount of water present such that the amount of water present is from about 28% to about 30% by weight of the solution, and heating the dispersion to a temperature of from about 80° C. to about 82° C. to form a solution; and b) cooling the solution to a temperature of from about 50° C. to about 55° C. to induce crystallization, further cooling the resulting slurry to a temperature of from about 25° C. to about 30° C., and adding an amount of ethanol that is from about 4.5 mL of ethanol to about 5 mL of ethanol per gram of L-glucose dispersed in step (a) to form L-glucose monohydrate.

1. temperatureheating the dispersion to a temperature of from about 80° C. to about 82° C.
2. customto form a solution
3. temperatureand b) cooling the solution to a temperature of from about 50° C. to about 55° C.
4. customcrystallization
5. temperaturefurther cooling the resulting slurry to a temperature of from about 25° C. to about 30° C.
6. additionadding an amount of ethanol that
7. additiondispersed in step (a)

ORD record

ord-52558a0b25a64fa69d17e5a075ddf1aa

Source dataset

uspto-grants-2013_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08470983B2