1-Tetralone → HCID 43809317, compound

HRID 1261561Notes

Reaction equation

HRID 1261561 reaction equation
[CH:1]([Mg]Cl)([CH3:3])[CH3:2].[C:6]1(=[O:16])[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH2:9][CH2:8][CH2:7]1>>[CH:1]([C:6]1([OH:16])[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH2:9][CH2:8][CH2:7]1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 107241-TetraloneHCID 178418918HCID 178418918, compound

Product 1

HCID 43809317HCID 43809317, compound

Procedure

According to Example 2, i-PrMgCl (1.10 mL; 1.10 mmol; 1.10 equiv) was reacted with 3,4-dihydro-1(2H)-naphthalenone (146 mg; 1.00 mmol) in the presence of LaCl3.2LiCl (0.33 M; 3.00 mL, 1.00 mmol, 1.00 equiv), the conversion was complete after 5 min (GC monitoring). After workup and careful evaporation of the solvents under reduced pressure, the desired product was obtained as colorless oil (180 mg, 95%). The analytical data were found to be in accordance with the literature data.

Workup

  1. customAfter workup and careful evaporation of the solvents under reduced pressure

Sources & evidence

ORD record
ord-b8f0cbea082c4498a21bef2bf5a2ac8d
Source dataset
uspto-grants-2013_06
Patent number
US08470982B2

Reaction notes

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