1,3-Diphenyl-2-propanone → HCID 12589845, compound

HRID 1261562Notes

Reaction equation

HRID 1261562 reaction equation
[CH:1]([Mg]Cl)([CH3:3])[CH3:2].[C:6]1([CH2:12][C:13]([CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[O:14])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>>[CH2:15]([C:13]([OH:14])([CH:1]([CH3:3])[CH3:2])[CH2:12][C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1)[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 75931,3-Diphenyl-2-propanoneHCID 178418918HCID 178418918, compound

Product 1

HCID 12589845HCID 12589845, compound

Procedure

According to Example 2, i-PrMgCl (1.10 mL; 1.10 mmol; 1.10 equiv) was reacted with 1,3-diphenylacetone (210 mg; 1.00 mmol) in the presence of LaCl3.2LiCl (0.33 M; 3.0 mL, 1.00 mmol, 1.00 equiv), the conversion was complete after 5 min (GC monitoring). After workup and careful evaporation of the solvents under reduced pressure, the desired product was obtained as white solid, mp=52−53° C. (241 mg, 95%). The analytical data were found to be in accordance with the literature data.

Workup

  1. customAfter workup and careful evaporation of the solvents under reduced pressure

Sources & evidence

ORD record
ord-db656a5db69949188137834fae6ec56b
Source dataset
uspto-grants-2013_06
Patent number
US08470982B2

Reaction notes

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