2-(2-Nitrophenyl)-2,3-dihydrofuran → 2-Tetrahydrofuran-2-yl-aniline

Participants

Reaction Steps

3a and 3b were carried through the reduction step to afford 2-tetrahydrofuran-2-yl-aniline (4) as set forth in Example 1.b (below). Analysis of this material revealed that both 3a and 3b were formed with the same major enantiomer, with an overall 70% ee. It is unknown whether the absolute stereochemistry of the major enantiomer was (R) or (S).

Provenance & Evidence