HCID 86672052, compound → HCID 70816758, compound

Participants

Reaction Steps

A mixture of 4-{(E)-3-[4-chloro-2-(pyridin-2-ylamino)-phenyl]-3-oxo-propenyl}-benzoic acid methyl ester (287 mg, 731 μmol) in methanol (12.2 mL) at 25° C. was treated with platinum (IV) oxide (8.3 mg, 36.5 μmol). The reaction was stirred under a balloon of hydrogen gas at 25° C. for 18 h. At this time, the reaction was filtered through a pad of Celite® to remove the catalyst. The Celite® was rinsed with a 10% solution of methanol/methylene chloride (2×30 mL). The filtrate was concentrated in vacuo to afford 4-{3-[4-chloro-2-(pyridin-2-ylamino)-phenyl]-3-oxo-propyl}-benzoic acid methyl ester (291 mg, quant.) as a dark green solid. The material was used without further purification.

Provenance & Evidence