Trifluoroacetic acid → HCID 67067426, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (2-{1-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-7-cyano-2,3-dihydro-1H-indol-5-yl}-1-methyl-2-oxo-ethyl)-carbamic acid ethyl ester (IV) (10 g, 0.02 mole), toluene (80 ml), triethyl silyl hydride (5.57 g, 0.04 mol) and trifluoroacetic acid (1.36 g, 0.01 mole), was stirred at 25-30° C. for a period of 6 hours. The reaction mass was quenched with water (50 ml) and toluene layer was dried over sodium sulphate. The solvent was evaporated under reduced to give 6.7 g of (V) as oil.

Provenance & Evidence