Potassium Hydroxide → HCID 77386307, compound

Participants

Reaction Steps

(2-{1-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-7-carbamoyl-2,3-dihydro-1H-indol-5-yl}-1-methyl-ethyl)-carbamic acid ethyl ester (VI), (3 g, 0.006 mole) was heated to reflux in toluene (25 ml) with KOH (2 g:0.03 mole) for 3 h. Reaction mixture was quenched with water and toluene layer was separated and washed with water. The organic layer was dried over sodium sulphate. The solvent was evaporated under reduced to give 1.84 g of (VII) as brown oily mass.

Provenance & Evidence